circRNA Custom Synthesis & Customization Service (1–4 kb)​

Our circRNA Custom Synthesis & Customization Service provides high-quality, sequence-verified circular RNA constructs tailored to your experimental or preclinical research requirements. Using optimized in vitro transcription and proprietary circularization strategies, we deliver highly stable circRNA molecules with superior resistance to exonuclease degradation and improved translational efficiency compared to linear mRNA.

We support full end-to-end circRNA design, including back-splice junction engineering, sequence optimization, internal ribosome entry site (IRES) integration, regulatory element selection, and chemical base modifications. Each construct is produced under stringent quality control, including purity assessment, circularization efficiency verification, integrity analysis, and optional sequencing validation.

This service is optimized for circRNA sizes between 1-4 kb, suitable for protein expression studies, gene regulation research, vaccine development, RNA therapeutics screening, and functional genomics applications. Flexible production scales, purification grades, and formulation formats are available to meet diverse research and development needs.